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(1) n. Megan Fox nickname.

Possibly a combination of two of the best things on the planet.

No... Actually, the combination of the ultimately sexiest woman on the planet (Megan Fox), and some other thing (Megatron) that has become cool just because Megan was in the same movie.

(2) n. Smoking hot.
(1) Have you seen the Transformers movie? Megantron is such a hottie.

(2) Guy #1: You see that chick on the beach? She's such a Megantron.
Guy #2: Are you stupid? Nobody matches the hotness of Foxy Megan.
Megantron by 3abooooo March 18, 2009
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Is a girl who is named Megan but whenever she consumes large amounts of alcohol turns from being a relatively nice girl to a crazy mean drunk annoying ass bitch hell bent on ruining everyone else's good time.
"Megan got too drunk last night and turned into MeganTron"
MeganTron by Luckyyou_2005 April 24, 2020

Megathon 

A challenging series of workouts led by Beachbody super trainer Megan Davies that consists of 2 live streaming workouts a day; spanning 3-4 days in a row.
These workouts occur once a month on the Beachbody on Demand Interactive workout platform and are designed to increase strength, improve cardio and endurance and burn fat.
Man, I still can’t walk up the stairs after doing the Megathon last week!
Megathon by EDGE-ucatedGuess June 6, 2022
-Megatron proceeds to beat poor Starscream-
Megatron by Security Puppet July 16, 2021
1. Leader of the decepticons

2. Deadliest NFL wide Calvin Johnson
1. "There goes Megatron terrorizing cities, and fighting optimus prime."

2. "Megatron with the 60 yard reception!"
Megatron by Ricky Tang July 6, 2014
Sentinels bitch
There goes Megatron getting betrayed yet again, this is a frequent problem
Megatron by Spider-Machine GP-7 April 11, 2021

megatrons bitch 

Person 1: Hey its starscream!
Person 2: No, thats megatrons bitch!
megatrons bitch by OriginWaffle January 11, 2021