Man-Five Share definition Flag To High five somebody as fast and hard as possible. Usually requires a run-up. This should end (if done correctly) in very painful, red hands. Dude! That man-five was awesome, my hand's so swolen I can't even move it! Man-Five by Samii-x January 12, 2009 0 0 Get merch Get the Man-Five mug. Buy Now — $32.95 See more merch