A Scottish name meaning I will kill you if you start trouble with my friends or my clan .
2.crazy muther scratcher that Will take great pleasure ripping your eye out so you can watch yourself getting your ass kicked .
Onlooker: Damn it man,what the the hell happened to you
Dumb ass that crossed the proverbial line:
I don't know I was shooting my mouth off and got MacFarlane'd
by gnarnold July 17, 2015
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Relying heavily on pop cultural references for humor, often hit or miss
Family Guy is guilty of Macfarlaning, most of its jokes are pop cultural references that can either be very funny, or just fail.
by zxre9 September 1, 2014
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The bloodiest of Scottish clans, deep devotion and loyalty
Don't mess with him, he's got the temper of a MacFarlane
by Fresria January 18, 2009
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A highly ridiculous person who habitually ridicules others; an egotard.
"The creator of Family Guy is a total MacFarlane."
by O'Brian McFinnigan February 6, 2023
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Ed Macfarlane is the lead singer of an amazing band called Friendly Fires, he is also known for being seriously attractive and one hell of a dancer.
i almost came when i saw Ed Macfarlane dancing in "Kiss of Life"
by strfckr August 28, 2011
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The creator of Family Guy, American Dad, and The Cleveland Show.

While the earliest seasons of Family Guy were genuinely funny, the half-baked, arrogant, overly self-indulgent douchebag known as Seth MacFarlane now mostly uses it as a vehicle for his anti-religious opinions (stated as facts) and takes on social issues, which are usually projected through Lois. To make Family Guy more of a cartoon, and less of a rant on right-wing Christians, he sprinkles in bits of Peter's buffoonery, Stewie-is-gay jokes, random swear words, 70's and 80's movie references (which approximately 3 per cent of the show's mostly teenage and twenty-something douchebag audience understands), et cetera. American Dad and The Cleveland Show are not used as frequently for this purpose, and are more or less cheap spin-offs of Family Guy, with their respective characters filling in each family role (Peter = Stan = Cleveland, and so on).
Come on, Seth MacFarlane, that's just pathetic.
by Mexistentialism August 5, 2011
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