mds 

Portuguese shorthand for Meu Deus, which translates in English to My God! Often used online

Person 1: Foi pra pria hoje e eu estive roubado... (I went to the beach today and I was robbed)
Person 2: Mds, que horrivél! (My god, how horrible!)

mds by HiVoltage December 14, 2014

Mds 

Masterbation Depervation Syndrom. The male form of pms, occurs when males fail to masterbate frequently enough inturn making them have all the bitchy qualities of a girl on her period.

Fran: "Dude, Jim is being a total bitch lately!"
Nicole: "Yeah he's totally mds-ing, gross..."

Mds by Sick of bitchy boys December 21, 2010

MDS 

not seeing a person for a certain length of time; missing seeing that person just because they're awesome

I was getting the MDS when I didn't see the Magster for awhile.

MDS by C'mon man! April 8, 2010

MDS 

Million Dollar Shit
of the same origins of MDP, you feel like you would have paid a million dollars to take that shit if you knew how much better you would have felt. usually occurs on trips, or other times when a bathroom is not readily available.

Zach: wow you look a little too happy coming out of that bathroom
CJ: dude MDS straight up.

MDS by ZAOS November 19, 2009

MDS 

Stands for Massive Dick Syndrome

"Man I had to go to the hospital and get surgery"
"Woah, for what!?"
"My girlfriend told me to get rid of my MDS."
"What's that?"
"Massive Dick Syndrome, she says it makes playing 'just the tip' is just like having sex with an average sized dick."

MDS by Slam_Diggity January 18, 2015

MDS 

Major Down Syndrome, when some one is very retarded.

My good friend raged on xbox live and punched his mum... something only someone with MDS would do...

MDS by AzFLYINGzFRIDGE May 10, 2011

MDS 

N. Micro Dick Syndrome

1. Connor F. is on the verge of MDS

2. Hey, how's MDS therapy been? I'm a survivor myself.

MDS by ChillChill June 9, 2011