To lose control of one's behaviour, to the point of verbal and/or physical aggression.
We've had to deal with quarantine protocols for a week and all residents have had to remain in their suites with no visitors. Some of the residents that have more advanced Dementia are losing their shit. They're becoming physically aggressive. But to lose one's shit comes more easily with quarantine than one would otherwise think
"To lose one's shit" has a very similar meaning as "to lose one's mind" Except your mind is brown, ugly, smelly, often watery, and is being dropped in, and clogging toilets at an alarming rate, as we speak.
To lose one's shit, can be used in this
case.
Guy: Was Kanye on grass when he wrote "Lift Yourself"?!
Guy 2: Fo' sheezy nigga, he lost his shit.