When a girl or group of girls like/give sexual pleasure to a boy who other boys find annoying or weird. These boys cannot figure out how this boy manages to get so many girls. Symptons include selling out your boys, backstabbing, being a snake in the grass, thinking with your balls instead of your brain and not being invited anywhere by guys.
Guy at a club:Dude how is he getting so much ass? He lives with his parents, cannot cut his own food, and is a total weirdo and a douche.
Other guy: I have no idea man. I guess he has john syndrome.
by WhereLegendsAreBorn February 7, 2010
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A syndrome commonly seen by prostitutes, whereby the John is unable to get arroused. If the prostitute is a high end well experience sex trade worker she will easily be able to isolate the psychological barriers preventing the John from attaining an errection and completing the service. However some prositutes may be forced into prostitution on the black market and are not experienced or highly intuitive and this may in some cases perpetuate little john syndrome indefinitely.
Anise experiences little john syndrome on a regular basis and soothes the John by feigning innocence to the johns issues at the john (aka crapper/pisser) and John's guilt and self-loathing for visiting her instead working and going home to his wife.

Lacuna experienced little john syndrome for the first time after Stanko brought her John into the motel room. When the John saw the disgust and fear in her eyes it served to perpetuate his little John syndrome.
by p@$$ing thr.ugh December 22, 2010
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Someone who has gay vibes, but isn’t actually gay
Nah, he just has John Mulaney Syndrome.
by Absolute twat September 25, 2020
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A condition in which you seem to trigger everyone's gay detectors, but you are in fact straight. This leads to you being asked if you are gay constantly and often being an icon among the LGBT despite being entirely straight.
"I think I was supposed to be gay. I think, like, in Heaven they built, like, three quarters of a gay person and then they forgot to flip the final switch, and they just sent me out and it was like, 'You marked that one gay, right?'
And it was like, 'Oh no! Was I supposed to?'" - John Mulaney creating John Mulaney syndrome
by simplyhopeless October 10, 2020
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When you decide to do something when your to old and forget what you had for breakfast. And expect to run the country, so thus you have John McCain Syndrome.
"Issac did you see Spencer speak today up on the stand, he must have John McCain Syndrome the way he was forgetting his speech and mumbling about his many houses."
by Parker James March 3, 2009
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1. (noun) A condition that occurs in a certain percentage of human males whereby the face gradually and irreversibly widens with the advancing onset of middle-age, transforming a once devastatingly handsome specimen of masculinity into a bloated parody of its former glory. Also known as Laurence Fishburne Pumpkinhead Disorder or the Widening. There is no cure, nor does the physical fitness of the subject have any impact.
Leo DiCaprio seems to be suffering from a mild case of John Travolta Syndrome.
by pototatoe head February 16, 2011
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An incredibly horrible condition in which you wear suits, discuss politics, and take constant ridicule for being John Gomez. In fact, you probably broke your leg sliding into a fucking base during baseball, and ended up on crutches for all of middle school for being such a fuck-up. John Gomez Syndrome is the equivalent of cancer, but to a more deadly degree.
Dude, why the fuck are you wearing a suit and talking politics?
I've been diagnosed with John Gomez Syndrome
That sucks
by RoxerMan October 24, 2014
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