hypo Share definition Flag slang, hypodermic injection. syringe, needle, or both. a small syringe used with a sterile needle for injection of material under the skin. im, iv.. "i filled the hypo up and stick it into the arm" hypo by hypo May 13, 2005 0 0 Get merch Get the hypo mug. Buy Now — $32.95 See more merch