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give it up 

to give in to one's sexual urges in a quick manner; usually referring to females
dang i was with abby for 10 mintes when she was ready to give it up!

give it up 

A request for praise which can be issued either by the recieving party or a third party.
give it up by Spirit Bear February 28, 2004

give it up 

To cease efforts now otherwise pointless
"Just give it up man, she's not interested in you."

"You'd better give it up, unless you're rollin' for a bitch-slap."
give it up by Krispy February 29, 2004

give it up 

You're not getting your money till you give it up.
give it up by Anonymous June 16, 2002

give it up 

phrase for "allow to have sex with", as if some girl's skanky cooter is like a wonderful gift that only a few very special dumb ugly men will have access to. Usually used by young girls who think their "body is a temple", or some stupid shit like that, and generally only use sex as a bargaining chip to further manipulate any man near them. A phrase usually used by the most conniving, manipulative, man-hating bitches on the planet - i.e. most of them.
"I'm not going to give it up until you buy me dinner, a new rolex, a sports car, and a mansion asshole! Get used to it 'cuz this is as good as it gets you piece of scum! I rule the planet because I have a vagina!"
give it up by muntumbo mo klick December 9, 2008