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When someone you're interested in and talking to all of a sudden stops and you have no idea why, or when they stand you up and don't tell you.
"I was really into Mari, but then she boarded Flight 370 I guess."

I was supposed to have coffee with Maxx, but I guess he got on Flight 370."
by jdod March 14, 2014
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2
"Hey, why are you so late?"
"Dude, my keys were totally Flight 370. Couldn't find them anywhere."
by J R Paulson March 15, 2014
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