When your profile picture doesn't look like you, but it looks worse than what you look like in real life. (Can also apply to myspace, but particularly facebook)
Guy:Have you seen my profile pic???
Girl:OMG its horrible. You have a serious case of Facebook Disease (FBD). You look way better in person.
Guy: Oh really? Thanks.
Girl:OMG its horrible. You have a serious case of Facebook Disease (FBD). You look way better in person.
Guy: Oh really? Thanks.
by Dough.Boy. June 14, 2008
Get the Facebook Disease (FBD)mug.