DUUUUUUUUUUUDE Share definition Flag "duuuuude" A phrase used by mexican friend when frustrated or angry. DUUUUUUUUDE thats not fucking funny that u peed in my snapple!!! DUUUUUUDE that exlax was harsh DUUUUUUUUUUUDE by Mex August 23, 2004 0 0 Get merch Get the DUUUUUUUUUUUDE mug. Buy Now — $32.95 See more merch