Mad scientist archenemy of the superhero Spider-Man; originated in Amazing Spider-Man #3. Named because his powers consist of four robotic tentacle-like arms, which were welded to his body in a laboratory accident. Played by actor Alfred Molina in the second Spider-Man movie. A much better supervillain than Venom, in my opinion.
All superheroes have archenemies: Superman has Lex Luthor, Batman has the Joker, and Spider-Man has Doctor Octopus.
Dr. Otto Octavius. A nuclear scientist and skilled inventor, he created a set of four robotic tentacles that were controlled with a neural interface. After a lab accident welded them to his body, he suffered brain damage and became a mad megalomaniac- and arguably the biggest headache for Spider-Man.
Ruler of Lake Titicaca. Rumored to have a bunghole that gets very angry if it does not receive toilet paper. Cornholio the Great is often seen walking around with his shirt over his head and his hands in the air, chanting songs about his power, and his bunghole.
"I am Cornholio! You do not want to face the wrath of my bunghole, for I need TP!"
Butthead: Shut up, Beavis! (uh huh huh huh)
Beavis: Um, okay. (heh heh heh heh).