che cazzo Share definition Flag Che cazzo means what the fuck in italian. The most common use is che cazzo uomo, meaning what the fuck man. Person 1:*whacks Person 2 in the face* Person 2: Che cazzo, uomo?!?! che cazzo by Lobby Bobby December 17, 2016 0 0 Get merch Get the che cazzo mug. Buy Now — $32.95 See more merch