Bunnyhopper's Syndrome 

Noun:
An affliction of the left hand's thumb muscles caused by overusing the spacebar in movement-heavy games such as Quake, Team Fortress 2, or any other keyboard and mouse game that involves a lot of jumping.
Common to those who have spent decades gaming on PCs. Symptoms include but not limited to a painful straining sensation in the webbing when opening the hand, a mild to moderate twitch in the thumb when resting the hand freely or when reaching for something, and painful thumb movements at the digit's full extension. See also Nintendo Thumb, Playstation Thumb, and Gamer Thumb for similar conditions

Bob had to give up speedrunning Half-Life because his Bunnyhopper's Syndrome flared up badly.

Bunnyhopper's Syndrome by Faux Pause May 23, 2021