Biggy Smalls Syndrome

A female consisting of a fat ass and no tits.

"Hey Ricky, dating that chick that has Biggy Smalls Syndrome will ultimately lead to your downfall."

by T.L. September 11, 2005

Biggie Smalls syndrome

When one womans breast is larger than the other.

Yo mama got one big titty and one little titty, they call the bitch biggie smalls! - Biggie Smalls syndrome

by Chips and subs November 17, 2010

Biggie Smalls Syndrome

When a woman has one breast larger than the other.

Amy is getting a boob job to cure her biggie smalls syndrome.

by El_Karnicero January 31, 2008