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Whenever something didn’t go your way it’s going going to be almost impossible to fully recover from.
Aw man, I heard that those two just broke up.. that’s a BIG OOF!
by Trashist April 09, 2018
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Jan 15 Word of the Day
The Nussy, or the “nose pussy”, if you will, was discovered during the corona virus pandemic of 2020. People that had to be tested for Covid-19 had to have their nose swabbed right where the brain connects, which often led to people rolling back their eyes and gagging.

A nose-swab-fetish developed from this, because we, as humans, ruin everything.
Oh fuck yeah, swab my nussy

Sir, please, I went to medical school

by Pogoextreme December 25, 2020
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An expression uttered when something is so cringeworthy, depressing, or hard to watch that that the expression OOF doesn't do it justice.
"Did you see the new Berry College logo?"
"Yeah...Big OOF."
by theRealColonelSanders December 24, 2018
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1. A Replacement for expressing pain, discomfort, or astonishment.
2. A way to announce that you have just witnessed ultimate savagery.
Friend 1: Ur mom gae.
Friend 2: Big oof.
via giphy
by Markymoist August 26, 2018
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When the situation is so bad you need a louder Oof sound but can't replicate it.
Person one: Your forhead is so large you could put solar panels on them and power an entire city.
Bystander: that was a Big Oof
by Fetus deletus 445 August 28, 2018
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The disappointment so great it can only be discribed by the noise of hitting rock bottom
Belle still having Sasha on Snapchat was the Biggest of Big Oofs
by Lennontaylor January 30, 2019
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when you see someone fall, you may say big OOF. when you fail a test you may say big OOF, or someone says something not funny, you can say big OOF. If you think you can apply the word big OOF to a sentence, you can probably say it.
boy friend: i forgot a condom

girl friend: big OOF
by BlueStripes March 15, 2019
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