A one night stand

1. The most common way to get AIDS/HIV. This is generally referred to as a booty call and involves Pitbull the rapper.

2. Shooting a ton of stupid no brain idiots in one night (generally used as zombies)

"I @#$@ Beyonce last night"
"Isn't that a one night stand?"

by Astupidwhiteboy September 25, 2017

Having a one-night stand with a loser

Doing it like they do it on discovery channel with a loser you just met in the night-life.

Jenny enden up having a one-night stand with a loser

Jessica was so drunk she ended up having sex with a geek that night.

Sarah did it with a loser she just met.

by Greenlander May 20, 2012