A Greasy Knob Share definition Flag When a man/woman with a large nose uses it in a very sexual way, particularly shoving it up someone butthole, or vagina. Louis: Hey Jonob! Give me A GREASY KNOB! Jonob: No I'm busy! A Greasy Knob by PETEYG223 January 21, 2021 0 0 Get merch Get the A Greasy Knob mug. Buy Now — $32.95 See more merch