47 chromosomes Share definition Flag Also known as trisomy 21, or Down syndrome - a genetic defect that leads to retardation and other mental disabilities. "Mitch is a fucking mental midget with 47 chromosomes, screw him!" 47 chromosomes by Mentis Debilitatum May 27, 2017 0 0 Get merch Get the 47 chromosomes mug. Buy Now — $32.95 See more merch