.io 

.io is the thing after a series of online games that is very popular

Agar.io lets play. Slither.io lets play that. Nope splix.io. and others

.io by Deltablue March 24, 2017

.io 

the host of all cancer

doctor: you have cancer
patient: oh no
doctor: to be specific,you have cancer.io
patient: *fucking dies*

.io by gearworks June 17, 2018

.io 

A game genre that originated in April 2015. It all started with Agar.io, a game where you have to eat like a pig and try to become the biggest player in the server. Not long after, Slither.io was released, followed by Wings.io, Diep.io, Splix.io, and many more.
Due to how simple they are to make, there are hundreds of .io games out there.

I remember when the first .io game was released.

Yeah...and the creator was...19 at the time? He probably thought his game would fall off the face of the earth...but instead he created an entire genre!

.io by Ubeenbamboozledson July 28, 2020

.io 

The top-level domain that used to be a fad to use for indie game projects with 1980s graphics, but nowadays lets you recognize a toxic Silion Valley start-up with the containerized framework crypto AI offerings to solve a problem, that wouldn’t be there without people like them, with more of the same.

You know… the ones with the huge stock photos and utterly useless text blurbs, that look like that of an asexual pickup artist peddling courses. The one seemingly run by 3rd-wave-coffee-sipping iDrones in skinny red plaid dungarees with black suspenders, black 50s glasses and side-combed undercut Hitler Youth / generic-diverse-curly hairstyles running the equivalent of jsLinux as their primary OS. The child of Juicero and a Musk project, not doing hardware, not software, but maybe something cobbled together from existing big projects that a skilled coder could put together himself in an evening, but it somehow presented as the greatest invention to ever save the world. Making Pied Piper look like the old and sane generation.

Not a single barefoot greybeard hacker who has worked on bare metal or Unix boxen in sight. They’re CoC-blocked.

A: Hey, have you heard of that great new thing, doteyeohh.io?
They.io made this amazing new invention that will change the world.io! The iMSmart.io!

B: They invented the … browser?

A: NO!! The text editor dot IO! It’s a platform! For frameworks! In a container! Using the new Crust language! See? You can install any scab you like! Let me just download this 128x128 pixel art animation! … hold on this is only terabit 6G… OK, … See?

B: It takes 12GB to run… a disguised Chrome browser in a disguised VM? … Why are my fans spinning up?

A: That’s just the AI gathering your neural data for Google Telemetry. It will make writing text super-easy! You don’t even *have* to make life choices anymore! Who doesn’t hate being an actual individual, right?

B: Nice OS you got there. If only it had a better text editor…

.io by Evi1M4chine December 4, 2022

Io 

One of the four Galilean moons of Jupiter, so called because of being discovered by Galileo. The most volcanically active object in the Solar system.

Hey, look in my telescope: you can see Io, Europa, Ganymede, and Callisto.

Io by antinous February 2, 2004

IO 

Acronym for Irrelevant One

Kimmie nicknamed herself IO after falling for Ben's crap for time one hundred. I hate to agree but he sure doesn't seem to care much about her feelings.

IO by Shyantha December 22, 2006

IO 

Acronym (Slang) for "I'm Out" when conversing using the Microsoft Communicator Software. v. The act of hastily departing an online collaboration session with little notice to others participating in the dialogue.

I am no longer part of this conversation as it is digressing rapidly; it will inevitably over-step that invisible moral line in the sand that uniquely distinguishes the employed from the homeless.

<message>
"Dude, I wanna dip it in the new workstudy sittin in the corner desk..."
<reply>
"IO"
<end of converstion>

IO by Big G Funk March 17, 2009