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A piece of shit wasteland in the middle of New Mexico full of underage whores, drug dealers, mexicans, indians, and rejects who were too poor to afford to live anywhere else. The reference Puke refers to the fact that it's so disgusting all you wanna do is throw up. The fact that it has the US's largest DWI arrests suggests that the only "fun" thing to do here is drink and drive.
Puke City is full of some of the ugliest people known to humankind, I suggest the large amounts of radiation buried underneath the ground lead to mutations in the populace.
Related Words

puke rip 

When you go on a no holds barred excursion that ends in puking usually involving smoking alot of drugs. usually carried out in a vehicle known as a puke ripper. sometimes something known as pukedogs may come into play, composed of puke and bunched up paper towels, thus ending the sequence.
person 1: HEY Weed Cray Slarb , care to go for a puke rip?
person 2: I have money. Cool. Yeah man.

person 1: Finish up your pukedogs Cray Snarb
puke rip by Cray Snarb March 9, 2010

puke and rally 

Verb: Vomiting (voluntarily or not) in order to continue or begin partying

Noun: The easiest transition from heavy day drinking into heavy night drinking
Person A: Let's party!!
Person B: I'm so tired, those irish car bombs at lunch knocked me out...
Person A: You need to puke and rally!

Person A: Man, I'm not feeling too well...
Person B: I just invited the volleyball team over to jacuzzi and get wasted. Puke and rally!
puke and rally by B.Wayne June 24, 2010

puke bomb 

Its when you drank way too fast because you thought you were cool but your really an asshole,then you decided to do those 3 shots of tequila and make an ass out of yourself further,then you went to take a piss and you felt sick and midway through your piss you gagged and then your stomach forcefully ejected a high powered puke bomb. asshole
Hey check out the wall in the bathroom stall it still has the meat stuck to it from my puke bomb.
puke bomb by CHICAGO GUY January 31, 2009

puke johnson 

Slapping style of bass playing associated with funk music.
I been diggin' on some Red Hot Chili Peppers lately. That little ugly dude in his drawers can get all over that puke johnson shit, man...
puke johnson by exitflagger April 30, 2008

puke puddle 

a puddle of puke. A pile of bullshit. A bundle of lies.

"Stick it out
Don't swallow the poisssonnn.
Spit it out
Don't swallow the lies..."

RUSH
Dogs go back to a puke puddle and lick it all up. Trained Pavlov dogs who can't think for themselves keep falling for all the bullshit coming from snake oil salesmen, corrupt politicians, money-stealing gurus, rip-off artists and more. People need to start thinking on their own and quit lapping up puke puddles.