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Uno Reverse Card 

Often referred to as "No U" uno reverse card is a statement you make after another says they will do something to you. This causes them to do it to themselves.
Person:"I'm gonna fockin shank ya BLUD"
Me:"Uno reverse card"
Person:*Shanks self*

Uno De Juno 

The holiest of holy days, Uno de Juno was originally a holiday created for non-mexican Spanish speakers. Sick of people assuming since they spoke Spanish that they wanted to celebrate the Mexican holiday of Cinco de Mayo, some Puerto Ricans and their white compatriots in New Orleans adopted Uno de Juno as their own day of holy celebration.

Intentionally misspelled, the first and only rule of Uno de Juno is that it is not celebrated on June 1st and the celebration usually consists of heavy drinking, drug taking and party-goers wearing poorly designed t-shirts.
Everyone got blackout drunk and Sam pissed himself, another great Uno de Juno was had by all.
Uno De Juno by Dooder11 June 14, 2013

Uno Reverse 

The main reason my friends hate me
“You’re dumb.”
Uno reverse.”

Uno Reverse Card 

The thing that is even more powerful than 'no u.'
Guy 1:U DUMB
Guy 2: NO U
Guy 1: UNO REVERSE CARD!!!!!!!
Uno Reverse Card by BOIIIIIYUYU November 11, 2019

Uno reverse 

The ultimate comeback, it will instantly decintigrate all those who hear it and will send the person the comeback is used upon to the shadow realm
Timmy: your mom gay.
Anthony : your dad lesbian.
Timmy: *plays uno reverse*
Anthony: *endlessly wanders the shadow realm*
Uno reverse by TheRoastyBoi March 29, 2018
Coming from Spanish translating literally to "one more." Common when drinking or during drinking games.

Popularized by the movie shanghai noon when the two main characters get drunk and convince each other to go another round asking "Uno mas?"
Drunk 1: I should stop now...
Drunk 2: Come on! Uno Mas?
Uno mas by $$$Danny$$$ January 18, 2009