To take part in sexual activities such as masturbation or to have sex with another person. Shizzle meaning "having sex" and nizzle being the vagina or penis etc.
by IDKbecauseREASONS March 18, 2016

anthony adair’s favorite word to say when he is hacking somebody on microsoft teams with his “shizzle” enzo medina
“sorry my shizzle i was just pulling a harmless prank on my shizzle i didn’t mean for it to go this far i swear” “HOW “DAIR” YOU ANTHONY YOUR GETTING EXPELLED YOU LITTLE PIECE OF SHIZZLE
by anthony adr January 11, 2021

It's a more calmer way of saying the curse word "shit", used in various expressions and ways .
Or another way of saying the slang "fo sho" to "fo shizzle"
Or another way of saying the slang "fo sho" to "fo shizzle"
Girl 1: Oh shizzle I just left my food..
Mom: Hey?! You know aren't allowed to curse until your thirteen
Girl 1: Mom chill, I didn't even say a curse word I just said "oh shizzle" geez
Mom; Oh! Okay..
OR..
Boy 1: Yo, you headin' to Drakes concert too?
Boy 2: Fo shizzle // Fo sho
Boy 1: Aightt see u there "Boy 2"
Mom: Hey?! You know aren't allowed to curse until your thirteen
Girl 1: Mom chill, I didn't even say a curse word I just said "oh shizzle" geez
Mom; Oh! Okay..
OR..
Boy 1: Yo, you headin' to Drakes concert too?
Boy 2: Fo shizzle // Fo sho
Boy 1: Aightt see u there "Boy 2"
by mickeykay August 5, 2023

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by wite boy March 23, 2005
