In sports, the opposite of "win and in"; describes a team's situation entering a game in which if the don't come out victorious, they are eliminated from postseason (the diffuse element is derived from the fact that the players on the team will go their separate ways at the conclusion of the season).
Man, if the Giants don't win this week, they can't make the playoffs.
Nobody in the whole wilde world would have thought that Brazil would lose a snow-white against Germany in the 2014 World Cup semi-finals. But they did.
Origin in English/Australian cricket vernacular, drinking sessions at pubs can be scored using cricket scoring format of wickets/runs (Aus) or runs/wickets (Eng), where runs are drinks, and having to urinate is a wicket.
You might tell your mates as you stand up that you just lost another wicket.