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lose and diffuse 

In sports, the opposite of "win and in"; describes a team's situation entering a game in which if the don't come out victorious, they are eliminated from postseason (the diffuse element is derived from the fact that the players on the team will go their separate ways at the conclusion of the season).
Man, if the Giants don't win this week, they can't make the playoffs.

Yeah dude, it's 'lose and diffuse' this week.
lose and diffuse by T. Coughlin December 22, 2010
Related Words

Lose the plot 

Get really angry and lose your self-control. Derogatory, as implies that it wasn't a reasonable reaction in the circumstances.
After Dad saw my picture on the front of the porno DVD, he completely lost the plot.
Lose the plot by Observer52 September 6, 2005

lose a snow-white 

If you score a single goal in a game and your opponent seven.
Nobody in the whole wilde world would have thought that Brazil would lose a snow-white against Germany in the 2014 World Cup semi-finals. But they did.
lose a snow-white by Crissov July 9, 2014

lose the 'tude dude 

Slang. It's how a guy says lose the attitude.
Son! Yeah dad? Did you take the books back to the library?

No! You're not my boss! Lose the 'tude dude
Wym? It's how a guy says lose the attitude

lose a wicket 

To have to urinate during a drinking session.

Origin in English/Australian cricket vernacular, drinking sessions at pubs can be scored using cricket scoring format of wickets/runs (Aus) or runs/wickets (Eng), where runs are drinks, and having to urinate is a wicket.

You might tell your mates as you stand up that you just lost another wicket.
1. "Damn it guys, just lost another wicket"

2. "Geez mate, if you lose a wicket this early you'll be up and down all night"

3. "I opened well, but am suffering from a middle-order-collapse (denotes a quick succession of wickets)"
lose a wicket by whitty January 27, 2005

lose bomb 

somebody who is THE biggest loser of all losers possible.
whether they actually lose at something like a game or they are plain old idiots.
As if you thought my sister would give you a ride home over me, you fucking lose bomb
lose bomb by kobekyler123 December 26, 2009