The leftover weed from a depleted vaporizer. It is often used to make canna-butter or sprinkled on food as an edible, since the the THC has been activated by the heat of the vaporizer.
Stoner 1: Damn, we’re out of weed!
Stoner 2: I got this duff , we could just eat some of that.
Stoner 1: Aw, hell yeah, let’s get blazed.
Stoner 2: I got this duff , we could just eat some of that.
Stoner 1: Aw, hell yeah, let’s get blazed.
by teaoutdoors June 16, 2021

The unattractive girl that a hot girl keeps around to make herself and her friends look better. Stands for "Dumb Ugly Fat Friend". THe DUFF tends to be a cockblock or a third wheel. See also "Grenade".
by G. Sherman August 11, 2003

by hillary's ex April 12, 2004

by Freakosaurus November 19, 2006

the act of locking the door behind you when you arrive to your place to lockout someone who may intrude or barge in unexpectedly.
by Pants007 January 20, 2009

by Cdoer July 11, 2010
