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Dio main 

Faggots that plays cooldown and spam knives and A FUCKING 1 FRAME GB
p1: "why do you suck so much cocks dude?"
p2: "I'm a dio main sorry i couldn't help it"
Dio main by allahswordidol June 9, 2021

Androxus Main 

A giga-chad who slays enemy cheeks, with a shlong the length of the golden gate bridge. Toys with the enemy kinessa, like a tigress playing with her prey.
Person one: yo did you hear Casper is an "Androxus Main"?
Person two: wow no wonder he is so sexy!
Androxus Main by xXChromeXx March 17, 2022

Side Main Thang 

Being In A Relationship But Having A Person On The Side That You Care About Deeply.
I Love My Wife But My Side Main Thang Is Life
Side Main Thang by Crim Diggla August 12, 2022

Reyna main 

Reyna mains are a combination of mega fags and no life skill-less homosexuals who spend 18 hours a day on valorant and the other getting pounded by other men. Fighting a reyna main will give you cancer while having a reyna on your team will surely make you want to shoot yourself. People who play Reyna are genuinely the most disgusting scumbags on the planet, none of her abilities actually help the team in any sort of way, making her a useless member of a protocol, which can be surely infuriating when your team lacks smokes or alarmbot. Outsmarting a Reyna main would likely make them ragequit
Guy 1: Why do I keep losing matches, I'm always top fragging because I'm such a good Reyna main
Guy 2: You absolute fucking retard, first of all, it says you don't have any way of covering flanks, your teammates keep getting ambushed because your selfish ass takes up another duelist space that could have went into flank control, oh yeah, you also would rather go in for a 2 kill then spend your precious time to defuse a spike, oh and that's not it, you went afk for 50% of the game to watch gay porn
Reyna main by Killercoffee March 20, 2023

The main cause of death for children under 5 

Me
What is the main cause of death for children under 5

Me

Rail the Main Vein 

To snort a line of cocaine off of a fully erect penis
Me: Yo, do you even rail the main vein?
12 year old on Xbox live: Yeah, fucker, I rail the main vein every day!
Rail the Main Vein by Blawkz February 9, 2015