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Duff

The shake at the bottom of a bag of drugs, including the seeds and stems in a bag of weed. Commonly used to describe the shake at the bottom of a bag of crystal meth.
Jeff: Hey, let me get a ball of that fire ice. Dan: All I have left is the duff, bro.
by jlthomas110880 November 25, 2020
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Duff

Designated Ugly Fat Friend

Usually the unattractive one in a group of friends. Basically the outcast
All my friends are beautiful, this means I'm the duff😭😔💔
by Starbeauty November 28, 2020
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Mickey duff

Mickey Duff was a well known boxing promoter whose name is now universally used as rhyming slang for marijuana.

Mickey Duff = Puff
If you want me to roll one up you’ll have to pass me my Mickey Duff.
by Loftier January 23, 2021
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DUFF

I see a lot of post say it’s not always just the designated ugly fat friend but the less attractive one. And I’d like to throw into play many attractive women use makeup and a lot of attractive women who may not use makeup sometimes want to be uglier. Pretty women and also not so attractive women who may not dress up or do their makeup usually have been sexually abuse and do not want to look pretty then them due to the predators seeking them out. And also noting the ones who do as well. Sometimes the uglier one in the group of friends is the prettiest or grows to be the prettiest inside but many men only date or fuck her to cheat and fuck her hot friends not realizing some ugly things are beautiful inside if you nurture it. So if your saying the word duff or any new term for it reflect on the ugliness in yourself for thinking that way before you assign a term to someone you base off looks. Don’t judge the book by it’s cover.
Man I thought she was a bitch and a duff but when my looks began to fade and others did too I realized she was the most beautiful and bloomed in time. While my hot chicks rotted inside. Leaving me with the duffs inside. Which made me a duff in all reality. Asshole people
by TwistedTaboos February 3, 2021
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Duff!

Someone who does not give a shit that he is the leader.
Dude! Do something, don't be duff!
by TrexMike March 17, 2021
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DUFF

A DUFF is a D- Dumb U- Ugly F- Fat F- Friend basically the girl or boy that tries to cockblock you when you are trying to make a move on a girl or a boy
Shut up you fuckin duff
by Kiddericc March 22, 2021
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uppa duff

did you hear about her? shes uppa duff
by pierrr April 10, 2021
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