Pheochromocytoma, a tumor of the adrenal medulla causing it to secrete large amounts of epinephrine and norepinephrine.
"My patient in room 214 has a jacked up kidney top so I had to prescribe her phentolamine."
by David Cartwright May 3, 2007
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A bunch of people getting roudy or having a good time together
Lets jack up our dicks!!
by Dopecoolkid September 17, 2017
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Briefly and rapidly masturbating a quasi-erect penis (or "semi") after foreplay leading to partner sex. In this usage the goal is not to masturbate to orgasm, but merely to get the penis stiff enough to penetrate vagina or anus under the assumption that the erection will stay sufficient throughout intercourse aka fucking, presumably leading to a successful climax (orgasm).
"I had to jack it up a little before I could go in, but I was afraid she'd think it was kind of gay, or that I didn't love her."

"Naw, man, you do what you gotta do. Go ahead and get it up a little more. If Dorothy has a problem with that, then why doesn't she use HER hand?"
by al-in-chgo February 21, 2010
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To be beaten severely about the head, face, body etc. i.e. "Jack up" from
being jacked up combined with shit box
"I will Jack Up Your Shit Box!"

"Tony landed one punch on that guy and really "jacked up his shit box"
by Morbog September 27, 2004
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It means that you are fucked, screwed, gonna die. Too bad for you.
I will jack you up 'til you bleed to death.
by Malicia Murder October 26, 2007
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An "up jack" is when you ejaculate into your own face and rub the semen into your nostrils.

You can up jack someone else by grabbing their penis and causing them to ejaculate into their face, at which time you rub the semen into their nostrils.
Oh man, I up jacked so much last night that everything still smells like my seed.
by Thadeous March 6, 2007
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