1. A particularly nasty, dirty, doped-out hooker. This is not your average prostitute. Ex. A cum-guzzling, crack-out whore with to much eye makeup, cum stains in her panties and ripped nylons.
2. The complete opposite of the "uptown girl"

3. Can also refer to a female of an ethnic minority from downtown or the wrong side of the tracks.
"Even if I was in the market for a hooker, I wouldn't get me no downtown bitch."
by Still Cuddy13 May 24, 2009
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A person's private area, coined by Dane Cook.
Dane Cook: ".. the first time you're gonna see the other person's downtown bonanza. And so you check it out and you hope that it's nice, and I'm happy to say she had a nice situation."
by euroboy September 23, 2005
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Fictitious area of London created by North American tourists. Referred to instead of learning the names of specific areas within England's capital city.
We were on holiday in London last summer.
Oh really, where did you go?
Oh like, downtown London.
What like Oxford Street? Covent Garden? Greenwich? Camden? Leicester Square?
Just like...downtown London...
by LondonUK March 7, 2008
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Euphemism for manual stimulation of the male penis by a dirty hooker (for money) employing the non-dominant hand and lubricated by bearing grease.
Todd was so poor, he couldn't afford a bj from a real hooker, so he had to settle for a downtown handshake from Holly Herpes behind the Jr. Food Store.
by leedlicks247rocker April 27, 2010
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An alternative name for a city of Toronto (in Canada), which was originally renamed by @tavajiia (aka Mrs.Downtown Canada 💅)on Twitter

Later the name was memed over by some Toronto-based Instagram accounts such as @6ixbuzz and etc.
Fam1: "Wagwan fam, hou wus the flight from the 6ix??"
Fam2: "whats the 6ix fam?"
Fam1: "Y'know, Torono"
Fam2: "Hell nah bruv issa Downtown Canada now"
Fam1: "Oh ya my bud"
by MishaMykha September 29, 2020
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She wasn't into the Space Dock so I settled for the Downtown 1
by Sirmixesalot February 10, 2013
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