The Matthew Perry combo is when you get high on both ketamine and buprenorphine at the same time. (His previous heart/artery issues combined with this combination is what caused his death, not the combo itself). You will indeed get zooted off your ass if you take this combo, and is a phenomenal concoction of scientific wonders that will take you from the 3rd dimension to the 3.5th dimension.
Dude, my friends and I took the Matthew Perry combo last night and got fucking blasted. Those buprenorphine strips are weak as fuck though, so we had to double down. Weak ass fucking government opioids, next time we'll have to try the lil peep combo.
by Dfenley December 8, 2024
 Get the Matthew Perry Combomug.
Get the Matthew Perry Combomug. The easiest combo, or sequence of connected moves in a fighting game, that one might possibly execute in a given situation.
You've already played every character three times.  Your problem is that you couldn't pull a combo out of a bag.
by Casey R Williams March 14, 2009
 Get the combo out of a bagmug.
Get the combo out of a bagmug. "Yo dude did you hear about how Larry and Tom plowed Jessica? Yeah bruh bruh, they gave her the ol' wombo combo"
by Tyler Durben June 5, 2016
 Get the Wombo Combomug.
Get the Wombo Combomug. Sexual act where a woman performs and engages in threesome sex with both a man and his father, considered to be the male opposite and reverse of a mother daughter combo.
by Doctor Whomst'd've what? August 10, 2025
 Get the Father son combomug.
Get the Father son combomug. Person 1: I asked her to send a nude and she sent a coochie combo
Person 2: Wow pussy and tit she must really like you
Person 2: Wow pussy and tit she must really like you
by Aa_Mm_Cc_ November 28, 2023
 Get the Coochie Combomug.
Get the Coochie Combomug. by Unseen433 February 10, 2021
 Get the Edgy combomug.
Get the Edgy combomug. A simple basketball move involving going ibetween your legs before utterly oblitirating your opponent.
Used in 1 on 1 scenarios.
Has a 100% success rate.
Normally used by people called JJ
Used in 1 on 1 scenarios.
Has a 100% success rate.
Normally used by people called JJ
by BIgBoyGOD October 23, 2019
 Get the JJ Combomug.
Get the JJ Combomug.