It is what people used to call Uncle, also known as Red Harlow in his youth. He was given this name due to his accuracy when shooting people and animals, as he only needed one shot. This also was given to him due to the nature of his sexual climaxes.
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"One for the big girls!" was what Bertha screamed as she watched Dr. Callie Torres get it on with McSteamy in Grey's Anatomy
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