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fo sho is a term used in tha 1980's originating in detroit. Mainly in tha drug neighborhoods, people or "hitmen" used this term in reference to a "head shot".
drug lord: "say did you pick off that nigga i told you about?"

hitman: "you awready know, it was a fo sho."
fo sho by JamelTOE March 10, 2009
A) A phrase that means: most definitely, without a doubt, that's my word
B) another way to say "for sure"
D: There's a party at my cousin's house. Wanna go crash it?
K: Fo sho!
fo sho by Merriweather July 15, 2006
for sure;positive;exact going to or gonna
me:hey you comin to da party this sataday?
friend:oh fo sho wid it ill be there
fo sho by julie October 8, 2004
Yo, look at that guys body, ain't it ripped?
fo sure
fo sho by Jackpot September 12, 2004
A term that is an agreement to anything. Also known as fasho, fosho, oh fo sho.
fo sho by Ja December 9, 2002
A shot to the head.

It is said in the tv show Gangland when Do was describing a way to do a hit.
"We had a, uh two guys, we called them Double Trouble. One person would hit you in the body, which would drop you, and the other person would put the what we call the fo sho."
fo sho by daboodeef197 September 24, 2011