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Screw yourself

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It means you're being/doing/saying something unpleasant and you need to go away and get lost.

A person who is upset at someone else's actions tells them to "Screw yourself". They could also say Fuck yourself instead but Screw is the cleaner version.
Q: How does "Screw yourself" or it's equivalent "Fuck yourself/Piss off" mean 'get lost'?

A: 'Screw yourself' implies before this bad transaction between 2 parties. The analogy in this sexual metaphor is that it WAS a mutual and pleasant affair between the 2 parties BUT now the offending party can do it all alone (Masturbate) because they're no longer welcome in each others company.
Ergo, screw yourself cuz I ain't fuckin' witchu no more
Husband comes home from work to hear wife yelling and complaining again at him as soon as he walked through the door but their children are present, so he responds: "You know what I'm tired of you telling me what's wrong every single time I come home from work. Go screw yourself, I'm out!"
by Priz13PersianSouls March 13, 2017
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Lady Macbeth is telling Macbeth to grow some balls so they can go kill King Duncan.
Macbeth:
If we should fail?
Lady Macbeth:
We fail?
But screw your courage to the sticking place,
And we'll not fail.
by Illegalkitty January 22, 2017
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Screw yourself

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To go fuck yourself. Insert your penis into your asshole, or your finger into your titty blob.
by AnonymousDefinition January 5, 2015
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screw your head on

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Screw your head on, get your shit together. Stop acting like an idiot and grow up.
“You really need to screw your head on.”
by unitedstrawberries August 6, 2023
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skrew you

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What someone says to you when there jealous of you
Skrew you ******
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put the screws on you

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Someone who trys by manipulation to control the action or thoughts of another person.
Geez, are you going to do everything she says? Don't you have your own life? She's really put the screws on you!
by KROISIN September 29, 2007
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