An unpleasant, cruel, or maliciously insane woman. The female incarnation of Evil Itself.

Often used to refer to female math teachers.

Taken from the the unpleasant character in Shakespeare's Macbeth.
Student: Who do you have for math next semester?
Friend: Mrs. Whitman, you?
Student: Roberts. Wait--Did you say Whitman?
Friend: Yeah, why?
Student: Watch out, man. She's like freaking Lady Macbeth.
by Lady Chevalier May 11, 2005
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What you call someone when they constantly wash their hands.
Kayleigh - *Washes hands for 50th time in 4 hours*
Me - "Woah! Lady Macbeth, get out the sink!"
by DEllis April 23, 2006
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when you get someone's cum on your hands and no matter how much you wash you just can't seem to get that damn smell out
Ugh, I have a total Lady Macbeth going on after that hookup, even though I showered twice!
by doorfish July 1, 2010
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The action of convincing someone to take violent action in order to remove someone in power who is above said person.
"This office needs a real leader someone who can take charge and cut out the middle man *drops knife* whoops" "Dude you are totally Lady Macbething me right now!!"
by 221B Bakerstreet May 27, 2014
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Washing your hands after masturbating on your period.
"What, will these hands ne'er be clean?... Here's the smell of the blood still: all the perfumes of Arabia will not sweeten this little hand... Wash your hands, put on your nightgown; look not so pale... To bed, to bed, to bed!" (Lady Macbeth Lady Macbething, Macbeth, Act 5, Scene 1)
by Lady MB November 20, 2016
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