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Out on a Big One 

To go out with every intention of getting absolutely off your trolley to the point of incoherent words being bubble blown in the ears of strangers, hanging around the necks of those within your party like a human lasoo, very likely ingesting illegal substances, coming home with make up down your face (whether yours or not) and continueing in a blur of sex, music and laughter until the sun comes up.
"I take it you're up to this on Saturday, yeah? We're out on a big one Saturday night, proper out out"
Out on a Big One by GDR11 September 18, 2017
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'The big one' 

Filling a balloon with semen and using it to bludgeon a family member or friend.
Mum, Harry is using 'the big one' on me!
'The big one' by Nut in it November 21, 2021
Related Words

go big or suck dick 

Alternative use of the phrase "go big or go home"

Schould not be used in family friendly matters
Family Friendly: If you go on the treadmill, go big or go home. *falls off treadmill" i guess i'll go home then.

Alternative: If you go on the treadmill, go big or suck dick. *falls off treadmill" ...

the big one 

The ultimate adventure, World War Two, 1939-1945. The summit of history.
my granpappy done killed 22 SS Officers and 72 screamin' Japanese in the big one, and now this generation tries to out-do him in quantities of gender!

That big of a deal 

20 of your kids are dead now so...
Hym "And that number will up if I am not giving the information I require. You a committed to covering this up because you don't want your nose rubbed in piss and I'm going to destroy your fucking lives the way you tried to destroy mine. It's that big of a deal. I don't think the parents are going to take an 'oopies' on this one."
That big of a deal by Hym Iam April 10, 2025

The Big One 

A real or imagined heart attack that a person experiences usually suddenly in response to a sudden distress or excitement. Originating from Redd Foxx's character Fred Sanford on the TV show Sanford and Son. Fred would clutch his torso with one hand, and extend his other arm out and usually exclaim as it's written in the example below, or some slight variation.

It's not a far cry from the expression to bite the big one meaning to die.
It's The Big One! Ya hear that, Elizabeth? I'm coming ta join ya honey!
The Big One by Sir Carlton May 26, 2025

The Big One

what they called me in high school
“Oh, god. Here comes the big one” one would utter as they hear the fat man theme song
The Big One by ScreamLoud763 November 9, 2025