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Used as an interjection in the same way as "Crap!" or "Damn!" and even "God!"
Some people, such as myself, find it more humorous to use the word "balls" in place of harsher words.

A few examples:
1) Getting killed in Counter-Strike.
2) Upon discovering your expulsion from college.
3) Upon discovering that you have testicular cancer.
(okay maybe #3 could've been left out.)
1) Balls.
2) Oh, Balls!
3) OH MY BALLS!!
Balls by Trey Beatty January 7, 2007
his balls swelled as she played with them in her hand
balls by dawn June 15, 2002
1. The testicles
2. A word to describe anger, forgetfullness, regret, dispair and many other emotions
3. A word usable in many expressions to express unwatingness
4. A childerens toy
1. Sally played with jacks balls.
2 i forgot to close the door, BALLS
2a Mom "go to school jim"
Jim "balls"
2b have a cugarette lucy
no they taste like balls
3 Whose balls are these that we have to go to work today, its thanksgiving.
4 Sally played with jacks balls.
balls by Bombino December 8, 2007
the testicles, usually stored in the scrotum unless you have problems!!!
I have 2 balls, lick em' bitch!
Balls by Horny old man November 11, 2002
to mean B.S. or ,theres no way. Also to mean one having no fear
Your idea didn't work "Balls!it didn't." " It took balls to tell him off."
Balls! by daveybaby April 3, 2006
Balls is a word you say to your friends too make them laugh.
ME: Balls.
CLASS: ha!