A particularly strong or annoying enemy in a singleplayer video game, typically a boss or other non-recurring entity.
Guy playing video games: "God, this boss has killed me like ten times now!!"

Guy's friend: "That's a Big Oof Nibba right there. Sorry, man"
by captconan May 11, 2018
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When something is a very melodramatic and a combination with collosal oof and oof
Me: I've heard that you got scammed in Steam

Friend: Yeah man :(

Me: BIG OOF Moment
by The Lag Guy March 23, 2020
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Something unfortunate that happened. "Oof" comes from a Roblox sound.
Guy 1: I wanna to get some ice cream for my 5th grade graduation.
Guy 2: The ice cream shop is closed.
Guy 1: Man, that's a big oof!
by littlemew June 1, 2021
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The worst type of work. Motivation ist instantly lost
My new assignement? Big OOF.
by John Treehouse February 6, 2021
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what tumblr girls say in response to anything you say; usually something negative that they don’t know how to respond to.
yeah dude my cat got diagnosed with cancer”
“big oof my guy
by dino.cogs October 16, 2019
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When someone roasted you I a group chat but you don’t know what to say so you say big oof
Person roasting you: your a banana split Sarah

You(Sarah): Big Oof
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