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Clusterfuckitis 

A disease or state of illness that, while similar to the Rube Goldberg Syndrome (a chain-reaction of diseases), differs in that it has no single origin and that the patient's future is completely uncertain.
You thought your brother's case of Rube Goldberg Syndrome was bad? Mine had a total case of clusterfuckitis... first he got some weird infection during a heart surgery, then 20 years later he went crazy and biked 3000 miles in one summer, and then the infection got back at him, he had to stop biking, so then his heart had to get used to him being lazy, but couldn't, so now he's breathing all funny, bet he's gonna get pneumonia from that bug now...
Clusterfuckitis by Mikey McM. February 1, 2009
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Clusterfuck 

"If you looked up clusterfuck in a dictionary, well you wouldn't find anything because clusterfuck isn't a real word. But if it was, there would probably be a picture of South Sudan next to it."
Clusterfuck by digeridoo. March 5, 2021

clusterfuckassery 

What you experience when the company you work for acquires another business that has nothing to do with your business and you have to integrate it.
This public relations fiasco has resulted in some real clusterfuckassery.

Clusterfucked 

When you're days away from coming out of your fourth COVID lockdown and your local health authority advises that a new and dangerous strain has just been detected and that it would be imprudent to open up until the source of the new cluster is identified. In this context, clusterfuck is a portmanteau of COVID cluster plus being situationally fucked.
Health Official: 'With the discovery of this new and highly transmissible variant, which is unrelated to the existing outbreak, the government will not be relaxing COVID restrictions as previously scheduled. In summary, you have just been clusterfucked"

Globular Clusterfuck 

A number of closely interrelated disasters that are connected to one another through their collective gravity.

The expression is the combination of the astronomical term globular cluster for group of stars and a clusterfuck.
The oil spill in the Gulf of Mexico will ruin corporate reputations, damage the fishing industry, kill countless fish and birds, pollute beaches and coastal wetlands. In short it is a globular clusterfuck that will take years to recover from.

World War I, the Spanish Flu, the Great Depression and World War 2 are viewed by many historians as a globular clusterfuck that spanned over three decades.

Clusterfuck 

A way to describe the current economic state and quality of life in South Sudan.
"Did you hear about South Sudan?"
"Yeah, it's a real clusterfuck"
Clusterfuck by blairjohnstone June 15, 2021

cloister fuck 

Several cloister tiles are placed within proximity to one another when playing Carcassonne.
"Geeze you've got a friggin cloister fuck over there."
cloister fuck by mshell December 24, 2008