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Clusterfuckitis 

A disease or state of illness that, while similar to the Rube Goldberg Syndrome (a chain-reaction of diseases), differs in that it has no single origin and that the patient's future is completely uncertain.
You thought your brother's case of Rube Goldberg Syndrome was bad? Mine had a total case of clusterfuckitis... first he got some weird infection during a heart surgery, then 20 years later he went crazy and biked 3000 miles in one summer, and then the infection got back at him, he had to stop biking, so then his heart had to get used to him being lazy, but couldn't, so now he's breathing all funny, bet he's gonna get pneumonia from that bug now...
Clusterfuckitis by Mikey McM. February 1, 2009
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clusterfucktastrophe 

An unnecessarily complicated calamity resulting from a series of poorly executed decisions or events.
Bad planning on your part should not necessitate an emergency on my part — don't set me up for a clusterfucktastrophe.
clusterfucktastrophe by twisterstory February 28, 2011

Clusterfucktician 

The messy way her brother kept his room made it obvious he was a real clusterfucktician.

My clusterfucktician of a boss at my last job couldn't organize anything and thrived on chaos.
Clusterfucktician by dallasmike August 31, 2013

clusterfuckation

When you are so fucked that the hole will take 90 lifetimes to get out of.
My debt is in a state of clusterfuckation.

Clusterfucktastrophy 

The perfect storm of everything that should never happen, yet still does. Somebody should obviously be dead from the magnitude, but miraculously everyone survived.
Councilman said that me driving an Odyssey dune buggy in the snow was a serious Clusterfucktastrophy.

Clusterfucktastrophe 

Something which feels catastrophic; like it is complete chaos due to being clustered, causing a since of being overwhelmed & unable to find a starting place.
"My life is a clusterfucktastrophe right now."

clusterfuckstival

A clusterfuck of epic proportions involving or affecting a massive number of people
This presidency has been a compounding clusterfuckstival from the very beginning, culminating in the year 2020.
clusterfuckstival by deanmccoppin September 29, 2020