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F5 is the function key to refresh a page on PC.

In Chinese/Japanese translation Web Novel and Light Novel communities, authors/translators will often have a regular time of the day that they'll upload the latest chapter. Practitioners of the F5 Sect have been known to repeatedly spam the F5 key near these times in the hope of being the first one to access the new chapter, and thus have the opportunity to make the first comment.

The 'Sect' is a joke referring to how many of the Chinese novels having martial practitioners belonging to various Sects (Clans, groups, etc.).

Therefore the users who single-mindedly hit the F5 key in pursuit of first comment ironically reflect the focus that'd be required of a martial cultivator in many of the novels that they are reading.
Lowlav (of Wuxiaworld forums):
F5 Sect is an organisation researching on the profound effects of throbbing F5, dealing with the order of rebirth. the pulse of internet. Cultivators of the laws of F5 are forever dominant in the comment sections all over the internet. It is a mystery with great power!

Ryuushima (Of Wuxiaworld forums):
They are a bunch of ---- that spam every chapter release with posts about being 1st , 2nd etc instead of talking about the actual chapter.

Minru (Of Wuxiaworld forums):
I refreshed the page and found a new skyfire chapter without a comment... instead of commenting first first first, i read the chapter. There still wasn't a comment so i nabbed first. Does this make ma F5 member because i got first or a F5 heretic because i read the chapter first?
F5 Sect by Deviant Antrax August 20, 2018
Related Words
f5 f5'd f54e F57 f5ing F5 Bomb F5 Bombing f5 Junkies F5 me F5 Moment

f5 Junkies 

A person who constantly refreshes their email inbox just in case someone has emailed them in the last 2 seconds
No matter how much of an F5 junkie you are, he's not going to email you!
f5 Junkies by rob heeney March 11, 2004

F5 Bombing 

A tradition on the Roblox forums. As the forums have pathetic software, you can easily do this trick. You go to your/someones topic and hold F5, to make the post get alot of views. This is a form of trolling as popular posts get a star as an icon, which annoys other users on the forum.
Me: Let's F5Bomb some shit!

*Holds F5*

Me: Yay, i held F5!

Someone Else: FFFFUUUU ANOTHER TROLL F5 BOMBING EVERYTHING AARGH REPORT REPORT REPORT

Reporting is reporting someone who spams/posts adult content.
F5 Bombing by WouterVL October 24, 2012
When Reloading, Refreshing, To Refresh, Time of the month, So on so forth(hehe).
"This is taking to long, I'm F5-ing this shit!"
the act of pressing the f5 key on your computer so the page refreshes
gayboy: do you have anymore replies on Y!A?
bigirl: i dunno i need to f5 this shit.
f5 this by bigirl2009 June 16, 2009

F5 yard stare 

The act of staring into ones computer screen for hours or even days on end. In a tunnel vision.
Oh no. Guys check it out. Dave´s got that F5 yard stare going again. Doing that facebook F5 loop.
F5 yard stare by Heimir Han January 23, 2009