Making life difficult has already been tried to convince people to wear masks. So the people that aim to make life already know they're going to get the same result since they're going to try the same thing yet again, except with vaccines instead of masks.
Making life difficult is going to get fought until the end by at least one person, no matter the excuse the people doing it use to justify what they're doing.
When applied to a woman in the workplace is HR terminology for the B*word.
In the post #metoo era "Difficult" has come to indicate a resistance to Harassment and SA.
Male Colleague (MC) to MC : I would like to to have Cindy on the team but I am told that she is "difficult" to work with.