DUFF

Acronym meaning designated ugly fat friend. This is the disgusting ugly fat friend that tags along with the hot chicks. Said hot chicks allow this as it makes them look less shallow and more attractive.

Ian: I've been tryin' to get Jenna alone for weeks now, but Bertha's always around.

Shawn: Ew, dude, Bertha's a total DUFF.

Ian: You think you could hold her attention while I talk to Jenna?

Shawn: That depends on how much you're willing to pay me.

by xdanielx October 3, 2008

DUFF

Designated Ugly Fat Friend/Designated Ugly Fat Fuck/Dumb Ugly Fat Friend

The infameous beer that Homer Simpson drinks on The Simpsons

a teenage pop star who has some talent but is over shadowed for being a "poseur"

That girl is a TOTAL DUFF

Homer Simpson always drinks Duff beer.

Hilary Duff is alright but everyone calls her a "poseur"

by Mike December 28, 2005

DUFF

The Dumb Ugly Fat Friend. Every hot girl has one, and their objective is to cock block all the guys. And for every DUFF you need a grenade and thats ur friend that would try to hit anything.

WOW! that DUFF's a bitch.

by ATICUS September 11, 2006

DUFF

Designated Ugly Fat Friend
an unattractive female who accompanies a group of females to either:
A. make the others feel better about themselves
B. gain access into an a social circle she would never be able to attain

Man, I was talking to this really cute girl. Next thing I know, her DUFF arrived and cock-blocked me!

by pidgezzz March 21, 2010

DUFF

Designated Ugly Fat Friend

If you don't know who the DUFF is in your group, odds are it's you

by KatLovesBands February 23, 2015

DUFF

Designated ugly fat fuck

Aye that bitch is a duff

by bigfloppykitty February 9, 2015

DUFF

Designated Ugly Fat Friend

Wow, who brought the Duff to the party!?!? Not cool guys...

by DUFF HUNTER August 15, 2009