A.K.A. Albert Haynesworth disease. Known to affect large, unfit individuals on the Redkins offensive line after 1 to 2 consecutive plays. Symptoms include phantom ACL tears, "back spasms" and other clearly non-life threatening falls to the turf.
Oh shit, the Skins $100MM off-season championship Albert Haynesworth looks like he must have broken his femure - he's really writhing around on the ground...

No, dipshit, that's just his Selective Fatigue Syndrome. He'll eat a donut on the sideline and will be fine after he takes another 4 series off.
by Bartholomew Turdstain October 27, 2009
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A mysterious illness that only affects fans of Star Wars.
Fan#1: I know you've been diagnosed with Star Wars Fatigue, but Jar Jar: A star wars story is playing...

Fan#2: I'd rather go see Fast and the Furious 32: The ghost of Paul Walker returns
by HanAsSolo May 29, 2018
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When someone has been up late playing Rocket League, they are too tired to get out of bed at a reasonable hour.
Don't expect Johnny to be getting up anytime soon, he is suffering from Rocket League fatigue.
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Noun. Abbrev. EFS

Suffered mainly by parents of young children, this ailment is experienced by being continuously exposed to entertainment/educational media for young children.
A: Have you seen Sarah lately?

B: Yeah, what's wrong with her? She's singing all these cutesy songs and keeps calling everyone Grover.

A: Edutainment Fatigue Syndrome. Spending too much time watching Sesame Street.

B: Can she be cured?

A: Probably. Needs to see something rated higher than TV-Y7.
by The Observationist July 5, 2011
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A state of chronic fatigue induced by having to constantly maintain compliance with the ever-increasing variety of rules, regulations and processes created by middle management bureaucrats in both public and private organizations.
I think I've got Compliance Fatigue Syndrome from all these rules and regulations we have to obey.
by Tiger Quoll February 2, 2017
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The immense feeling of tiredness that follows ejaculating, whether masturbation or sex. The reason why many men masturbate in bed so they can fall asleep easier.
Last night i couldn't fall asleep, so i jacked off and the post-jizz fatigue helped me fall asleep right away.
by bob mcgee jr July 14, 2011
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The condition of football fans getting tired of watching the same teams (Bama & Clemson play every year in the college football playoff. Also known as program envy. Particularly affects inferior football teams, fans, players and historically underachieving programs like the South Carolina Gamecocks.
I can't take it anymore! I have Clemson Bama fatigue again.
by Oculusprime January 5, 2019
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