Duff 

A blonde chicks vagina.

"Hillary's duff"
"Go get you some of that duff over there"
"I bet that chick has a nice duff"

Duff by Fagboyslim88 January 13, 2017

Duff 

dumb ugly or fat friend...

Becky invited her duff so she doesnt get wasted and blows any willing cock within sucking distance

Duff by NorCal Slanger March 27, 2017

DUFF 

Abv. For Designated Ugly Fat Friend. Usually the one person more approachable in a group and the one who is less attractive than all the others in the group. Sometimes a girl will approach a DUFF and start to flirt but after a while will begin to ask questions about another hotter member of the group.

Man #1: Dude, that's your job as the DUFF
Man#2: What did you just say to me?
Man#1: You're a DUFF, Designated Ugly Fat Friend.
Man#2: That's so messed up.

DUFF by Sugary sweet April 7, 2017

duff 

dumb ugly fat friend

"cant she see she is the duff"

duff by go to bed April 19, 2017

Duff 

To scarf down food at a rapid pace; to eat large amounts very fast.

After I smoke, all i want to do is duff and sleep

Duff by Fontaine June 30, 2017

Duff 

1. Designated Ugly Fat Friend
2. A more polite way of saying ass or butt

1. She's such a Duff
2. My Mom always tells me to get off my duff and go outside

Duff by SauceMilliken July 31, 2017

Duff 

Beer you wish you could have but never will.

I'm craving some duff right now bro.

Duff by lemonberrypie August 4, 2017