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1) a declaration of ignorance of question or situation;
2) an assertion of indifference to or transcendence beyond conventional wisdom.
Simpson-Homer Simpson, he's the greatest guy in his-tor-y. From the town of Springfield, he's about to hit a chestnut tree. D'oh!

Homer When the house is on fire : When a fire starts to burn there's a lesson you must learn, something-something then you'll see, you'll avoid catastrophe, D'oh!
D'oh by William May 6, 2004
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Meaning cool or good; like dope meaning cool without the "pe" sound.
This song is D-OH
D-OH by Dr. Rellim February 8, 2010
D&OH (or DNOH pronounced dee-noh) - Short for the phrase "Duh and or Hello" made popular by Jon Benjamin's character from Archer, Sterling Archer. A sarcastic way of answering 'yes' to an obvious question.
Gay Guy1: Look Archer, in spite of your personality you get plenty of women right?

Archer: Uh, D&OH!

Gay Guy1: Well, D&OH, just act like you normally do around women...
D&OH by jdrsqrd August 22, 2011
Used for Expressing one's dislike for the current situation

Accepted into the Engish Oxford Dictionary and thus is a real word
d'oh by Duder October 1, 2003
an expression after one has done a stupid thing
(i walked into a wall.) d'oh!!!
d'oh by Kevin G August 13, 2002

tivo d'oh 

The act of inadvertently watching a commercial as part of a digitally recorded program.
Mary: Why are we watching this commercial instead of fast forwarding it?

Tibor: Tivo d'oh! I'll fast forward until we see Anderson Cooper again.
tivo d'oh by Herbal Klimt December 27, 2009

D'oh Freaking Pizzas! 

A phrase of expression of mass anger, hatred, grief, or dislike. Usually toward deaths in video games. Used by Chuggaaconroy.
Me: Let me show you a cool glitch on this game!

Friend: Alright!

*dies in the game by accident*

D'oh Freaking Pizzas!