1. An expression of grief or anger, derived from the realization of an idiotic act or mistake.
2.An expression of whoa.
"Why aren't you wearing any pants Simpson?"

by DDarko April 21, 2003
An exclamation of distaste or dislike. Originating from Homer Simpson. Actually accepted into some dictionaries (such as this one.)
<Homer> You might say he's barkin' up up the wrong Bush! Heh heh heh.
<HomersBrain> There it is, Homer. The cleverest thing you've ever said, and nobody heard it.
<Homer> D'OH!
by Bastardized Bottomburp August 23, 2003
1.To imply that one has done something stupid, accompanied with a slap on one's head.
2.Homer Simpson's catch phrase.
Homer (after walking into a wall):
by person yo-yo October 4, 2003
used when something goes wrong
Person: Did you remember to lock the door?
You: D'oh!
by bread infection October 25, 2005
Used for Expressing one's dislike for the current situation

Accepted into the Engish Oxford Dictionary and thus is a real word
by Duder October 2, 2003
an expression after one has done a stupid thing
(i walked into a wall.) d'oh!!!
by Kevin G August 14, 2002