Typically used in terms like cisgender or cissexual. Cisgender people are those who remain their gender observed at birth by the doctor, cissexual refers to people who are attracted to those who are their birth gender. Can also be used as an acronym like "Comfortable In Self" which can imply those who are choosing a different gender than at birth (transgender) aren't comfortable with their existing self prior to transitioning which is true given gender dysphoria as a mental illness.
This guy is cis, he was born a male and chose to remain a male rather than transition to another gender.
by thepcwiz101 March 11, 2024
Get the cismug. The fatigue a trans or nonbinary person feels after having to defend or explain their personhood and identity to a cis (cisgender) person.
Person A: Isn’t that the sixth time your supervisor has misgendered you?
Person B: Yeah, and it’s the sixth time today I’ve had to correct her on my pronouns; I feel like she’s never going to get them right. I have so much cis fatigue right now.
Person B: Yeah, and it’s the sixth time today I’ve had to correct her on my pronouns; I feel like she’s never going to get them right. I have so much cis fatigue right now.
by hobbiting_around August 10, 2021
Get the Cis fatiguemug. 
When cis people take over a trend,slang or a thing that the trans community has made and cis people turn it to make it fit their agenda.
by blingygeo April 18, 2022
Get the cis-ifiemug. a bottle of "cis tears", "support your sisters not just your cis-ters" **these are from gifs displayed on urban dictionary
by theskyisrose April 13, 2023
Get the Cismug. A term appropriated from chemistry by mentally ill freaks and used to try and marginalize normal people.
by Callivan January 18, 2023
Get the Cismug. The holy water to petrify the devil; aka the single combination of identities that SJWs and the current state lefties are at (radical liberalism) and are losing their shit over. It came with the rise of "wokeness" in the 2010s, particularly.
*Usually a way to refer to those modern feminists and LGBTQ+ advocates and allies despise. Often said, when serious/unironic, without care or awareness of how sexist, racist, and overall discriminatory it is, or as a propagating phrase to indoctrinate and mislead. Rose to popularity through TikTok, Twitter, and Tumblr; the smelly depths of the Internet, really.
Sometimes accompanied with "old," like when referring to those who made the Roe v. Wade decision.
Simply put, the final boss modern day liberals claim are perpetually feeding into their suffering.
*Usually a way to refer to those modern feminists and LGBTQ+ advocates and allies despise. Often said, when serious/unironic, without care or awareness of how sexist, racist, and overall discriminatory it is, or as a propagating phrase to indoctrinate and mislead. Rose to popularity through TikTok, Twitter, and Tumblr; the smelly depths of the Internet, really.
Sometimes accompanied with "old," like when referring to those who made the Roe v. Wade decision.
Simply put, the final boss modern day liberals claim are perpetually feeding into their suffering.
Blue-haired they/them: Leave it to you straight, cis, white men to take away my rights as a non-binary, pansexual girlboss.
Their estranged father: You were exactly who you hated before 2018.
Their estranged father: You were exactly who you hated before 2018.
by thoughtscanberead December 4, 2023
Get the Straight, cis, white menmug.