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This is a sign of complete indifference. See it's counterpart posh.
(I may be wrong but I don't care):
Bob: that's impossible.

Me: pish.

(I don't care what the ---- you think):
Bob: that is the most idiotic thing you could do.

Me: *glare* pish.

(A random interjection saying that you don't care)
Bob: So, about the latest blah blah blah boring math blah yawn blah blah ...

Me: pish.
pish by 1qazxsw2 January 3, 2011
Related Words
pish pish posh pishy pish flaps pisher pish-tosh Pished pishart pishpish pisha
Concurrent with popular opinion, it is in fact possible to die as a direct result of management assignments. The first known case was a result of a management course at Perth Collage (sic).

The condition, known as Perth (Collage) Induced Self Harm (or PISH) is common among those taking management courses. Symptoms can include burnt foreheads (from falling asleep against computer monitors), painful index finger (from repeatedly flicking through difficult to use online texts on deciphering management speak) and in some cases a small depression in the candidate's desk (from repeated head-banging).

If not treated quickly through Nocturnal Infusions Gained from Highly Tasty Solutions, Obtained Under Tempo (NIGHTS OUT), the condition can quickly progress, leading to total psychological breakdown, self-severance of limbs through chewing and eventually death from choking on a managment course folder.

However prevention is better than cure, and so it remains best to stay objective while undertaking management work, and let the mind-numbing jargon wash over you. If you do this, you may even get as far as the second question before breaking down.
Oh dear - I feel a case of PISH coming on...
PISH by Jocasta Devillneuve February 28, 2008
When you go to the bathroom and it is a gamble. It could be a piss or a it could be a shit.
I just had Taco Bell for breakfast after drinking beer 30 all last night. I am going to take a pish.
Pish by Lake5ide89 April 7, 2017
(If someone is near your vagina) "Hey get out of my pish!"
Pish by funnyfunnypish1234567899 December 11, 2010
short for pish-posh, meaning "that's nonsense", "it doesn't matter", or "who cares"
O pish! No one cares what he thinks anyways.
pish by autumn fox December 18, 2009
A sound
Prounounced "Pi-ish"
It's like Pit, without the 'T' and plus 'ish'

penis cakes.
I pish on you, you foo'.
Pish by JBLJRS March 5, 2008