Pandora's box 

Refers to a slutty girls vagina; is typically used when one sleeps with a slut and "opens" pandora's box.

Damn, Marcel, you slept with her? You just opened pandora's box!

Pandora's box by Twotone867 March 5, 2009

Pandora's Box 

Pandora was a Greek woman with an extremely large box that was frequently opened by all of the townspeople, (even the women), (the women who liked boxes!). Sometimes Pandora would hold large picnics where she would offer her box to everyone. If they were lucky they would also receive ketchup.

Pandora was very generous with the use of her box, however some people refused because they thought it was dirty as it had been passed around a few too many times! It was quite the Pandora's Box!

Tyreece looked forward to meeting Pandora for a taste of her box.

Pandora's Box by CockBlocker November 24, 2004

Pandora's Box 

When you microwave your fuckn weed and then open the microwave.

"I put my joint in a windowsill so my parents wouldn't find it, and it froze overnight. So I microwaved it to soften it up and when I took it out of the microwave it was like opening Pandora's Box."

Pandora's Box by anonymous December 3, 2020

Pandora's Box 

The combination of thinking inside the box and outside the box

how I personally think about the situation is on pandora's box

Pandora's Box by KydraTheRapHydra December 18, 2021

Pandora's Box 

In Project Zomboid, Pandora's Box means when you open a door of any building and a horde of zombies appears after you open it. catching you off guard and most likely resulting in your death

Person: "Damn, all 4 of us died because we opened Pandora's Box." (Louisville Grand Ohio mall)

Pandora's Box by Zepherixs August 17, 2023

Pandora's Box Effect

The effect that transcends one's curiosity into an overactive drive/need to experience something, regardless of the ending possibilities. It is different from peer pressure since it does not require external forces, but is similar to physiological effects, such as being horny.

A: I think I wanna get a prostate exam, just to see what it's like
B: That's the Pandora's Box Effect, dude. Don't fall for it.

A few days later

A: I got a prostate exam.
B: You look a little different.
A: You think?

Pandora's Box Effect by NTRP January 6, 2021

opening Pandora's box 

Learning how to shoot up on your own

Shooting up yourself is kind of like opening Pandora's box.

opening Pandora's box by M0n$t3r August 18, 2014