According to Greek legend, the first woman, Pandora, was actually sent as a curse to Zues' men (See, you knew it was true, guys) and was given a present upon her marriage. The present was a box that she was told never to open. Needless to say her curiosity got the better of her (like eating forbidden fruit) and she unleashed eight demons unto the world. The first seven being the seven deadly sins, and the last, which she managed to capture, was hope.

Today, much like christianity's idea of biting forbidden fruit, opening pandora's box refers to getting into a situation over which one has very little control over.
The assassinating on Austrian Archduke ferdinand in 1914 opened pandora's box for Europe.
by Kung-Fu Jesus April 16, 2004
Get a pandora's box mug for your father-in-law Günter.
A particular box in which someone might own for stashing sectrative objects in. Preferably lockable boxes. Such as: paraphernalia/own top secret stuff/possiblly illegal things/ ect.
This is sure going in my pandora's box..
by watchingslenderman September 12, 2012
Get a pandora's box mug for your boyfriend Callisto.
1. A delicate, sensitive issue or event that, if not managed and handled carefullyl with great care, guile, nd intelligene, can turn into the worst mess one could not even come close to obtaining any type of visibilit as it is greater than anything one could possibly imagine.

2. Has potential to result in shit-show, and prefers that end.
pandora's box

"Anything associated with race will involve pandora' s box so BE_WARE!"
by Akhenatron February 12, 2016
Get a pandora's box mug for your Uncle Günter.
an extremly powerful spell in final fantasy VII that inflicts mass damage to all enemies.
When you cast pandora's box things get pwned.
by some guy December 15, 2004
Get a pandora's box mug for your dog Vivek.
A vagina that contains every known S.T.D or S.T.I
Guy : " Hey, who is that ?"
Other Guy : " That stank ho? You don't wanna mess with her; personally, I wouldn't touch her with a nine and a half inch pole."
Guy : " Why?"
Other Guy : " Dude, she's got Pandora's Box."
Guy : "Oh sick! Someone get hazmat."
by nasty pete March 04, 2013
Get a Pandora's Box mug for your daughter-in-law Helena.
Refers to a slutty girls vagina; is typically used when one sleeps with a slut and "opens" pandora's box.
Damn, Marcel, you slept with her? You just opened pandora's box!
by Twotone867 March 05, 2009
Get a Pandora's box mug for your guy Paul.